6IO0
Human IDH1 R132C mutant complexed with compound A.
Summary for 6IO0
Entry DOI | 10.2210/pdb6io0/pdb |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, (2E)-3-{3-[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carbonyl]-1-methyl-1H-indol-7-yl}prop-2-enoic acid, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
Functional Keywords | iso-citrate dehydrogenase, allosteric inhibitor, nadph, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 97010.90 |
Authors | Suzuki, M.,Baba, D.,Hanzawa, H. (deposition date: 2018-10-29, release date: 2019-10-30, Last modification date: 2024-03-27) |
Primary citation | Machida, Y.,Nakagawa, M.,Matsunaga, H.,Yamaguchi, M.,Ogawara, Y.,Shima, Y.,Yamagata, K.,Katsumoto, T.,Hattori, A.,Itoh, M.,Seki, T.,Nishiya, Y.,Nakamura, K.,Suzuki, K.,Imaoka, T.,Baba, D.,Suzuki, M.,Sampetrean, O.,Saya, H.,Ichimura, K.,Kitabayashi, I. A Potent Blood-Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model. Mol.Cancer Ther., 19:375-383, 2020 Cited by PubMed: 31727689DOI: 10.1158/1535-7163.MCT-18-1349 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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