6IMI

Crystal structure of PDE4D complexed with a novel inhibitor

Summary for 6IMI

• Entry DOI: 10.2210/pdb6imi/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ZINC ION, ... (6 entities in total)
• Functional Keywords: pde4d, inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 81549.75

Authors

Zhang, X.,Su, H.,Xu, Y. (deposition date: 2018-10-23, release date: 2019-10-23, Last modification date: 2024-03-27)

• Primary citation: Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y.; Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.; J.Med.Chem., 62:5579-5593, 2019; PubMed: 31099559; DOI: 10.1021/acs.jmedchem.9b00518

Experimental method

X-RAY DIFFRACTION (1.46 Å)