6ID2

Crystal structure of H7 hemagglutinin mutant H7-AVTL (P221T) from the influenza virus A/Anhui/1/2013 (H7N9)

6ID2 の概要

• エントリーDOI: 10.2210/pdb6id2/pdb
• 分子名称: Hemagglutinin HA1 chain, Hemagglutinin HA2 chain (3 entities in total)
• 機能のキーワード: influenza virus, h7n9, hemagglutinin, viral protein
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 332640.06

構造登録者

Gao, G.F.,Xu, Y.,Qi, J.X. (登録日: 2018-09-08, 公開日: 2019-11-27, 最終更新日: 2024-11-13)

主引用文献

Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F.
Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin.
Cell Rep, 29:2217-, 2019

PubMed Abstract: Since 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,600 human infections, posing a threat to public health. An emerging concern is whether H7N9 AIVs will cause pandemics among humans. Molecular analysis of hemagglutinin (HA), which is a critical determinant of interspecies transmission, shows that the current H7N9 AIVs are still dual-receptor tropic, indicating limited human-to-human transmission potency. Mutagenesis and structural studies reveal that a G186V substitution is sufficient for H7N9 AIVs to acquire human receptor-binding capacity, and a Q226L substitution would favor binding to both avian and human receptors only when paired with A138/V186/P221 hydrophobic residues. These data suggest a different evolutionary route of H7N9 viruses compared to other AIV-subtype HAs.

PubMed: 31747596
DOI: 10.1016/j.celrep.2019.10.047

実験手法

X-RAY DIFFRACTION (2.705 Å)