6IBM

Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclosulfate ME776

6IBM の概要

• エントリーDOI: 10.2210/pdb6ibm/pdb
• 関連するPDBエントリー: 6IBK
• 分子名称: Alpha-galactosidase A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: hydrolase, glycosidase, galactose, carbohydrate
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97160.99

構造登録者

Rowland, R.J.,Wu, L.,Davies, G.J. (登録日: 2018-11-30, 公開日: 2019-10-09, 最終更新日: 2024-01-24)

• 主引用文献: Artola, M.,Hedberg, C.,Rowland, R.J.,Wu, L.,Raich, L.,Ferraz, M.J.,Kytidou, K.,Marel, G.A.,Codee, J.D.C.,Rovira, C.,Aerts, J.M.F.G.,Davies, G.J.,Overkleeft, H.S.; Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease; Chem Sci, 2019; DOI: 10.1039/C9SC03342D

実験手法

X-RAY DIFFRACTION (2.07 Å)