6IB0

The structure of MKK7 in complex with the covalent 4-amino-pyrazolopyrimidine 3a

6IB0 の概要

• エントリーDOI: 10.2210/pdb6ib0/pdb
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 7, 1-[(3~{R})-3-(4-azanyl-3-ethynyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]prop-2-en-1-one, TETRAETHYLENE GLYCOL, ... (4 entities in total)
• 機能のキーワード: mkk7, inhibitor, covalent, transferase, jnk, kinase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36637.41

構造登録者

Wolle, P.,Hardick, J.,Mueller, M.P.,Rauh, D. (登録日: 2018-11-28, 公開日: 2019-02-27, 最終更新日: 2024-01-24)

• 主引用文献: Wolle, P.,Hardick, J.,Cronin, S.J.F.,Engel, J.,Baumann, M.,Lategahn, J.,Penninger, J.M.,Rauh, D.; Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.; J.Med.Chem., 62:2843-2848, 2019; PubMed: 30768270; DOI: 10.1021/acs.jmedchem.9b00102

実験手法

X-RAY DIFFRACTION (2.6 Å)