6IAP

structure of human NKp46 in complex with antibody NKp46-1 and NKp46-4

Summary for 6IAP

Entry DOI	10.2210/pdb6iap/pdb
Descriptor	Natural cytotoxicity triggering receptor 1, Fab NKp46-4 light chain, Fab NKp46-4 heavy chain, ... (6 entities in total)
Functional Keywords	therapeutic antibody, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	113726.20
Authors	Roussel, A.,Amigues, B. (deposition date: 2018-11-27, release date: 2019-06-12, Last modification date: 2024-01-24)
Primary citation	Gauthier, L.,Morel, A.,Anceriz, N.,Rossi, B.,Blanchard-Alvarez, A.,Grondin, G.,Trichard, S.,Cesari, C.,Sapet, M.,Bosco, F.,Rispaud-Blanc, H.,Guillot, F.,Cornen, S.,Roussel, A.,Amigues, B.,Habif, G.,Caraguel, F.,Arrufat, S.,Remark, R.,Romagne, F.,Morel, Y.,Narni-Mancinelli, E.,Vivier, E. Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity. Cell, 177:1701-1713.e16, 2019 Cited by PubMed: 31155232 DOI: 10.1016/j.cell.2019.04.041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation