6I6C
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 2
Summary for 6I6C
Entry DOI | 10.2210/pdb6i6c/pdb |
Descriptor | Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1~{R},2~{S},4~{S})-~{N}-(3-chloranyl-4-cyano-phenyl)sulfonylbicyclo[2.2.1]heptane-2-carboxamide, ... (5 entities in total) |
Functional Keywords | sepiapterin-reductase, oxidoreductase, proteros biostructures gmbh |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 62495.83 |
Authors | Alen, J.,Schade, M.,Wagener, M.,Blaesse, M. (deposition date: 2018-11-15, release date: 2019-07-10, Last modification date: 2024-05-15) |
Primary citation | Alen, J.,Schade, M.,Wagener, M.,Christian, F.,Nordhoff, S.,Merla, B.,Dunkern, T.R.,Bahrenberg, G.,Ratcliffe, P. Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62:6391-6397, 2019 Cited by PubMed: 31244106DOI: 10.1021/acs.jmedchem.9b00218 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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