6I30

Crystal structure of the AmpC from Pseudomonas aeruginosa with 1C

6I30 の概要

• エントリーDOI: 10.2210/pdb6i30/pdb
• 分子名称: Class C beta-lactamase PDC-301, (3R)-3-(cyclohexylcarbonylamino)-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid (3 entities in total)
• 機能のキーワード: cyclic boronates, antimicrobial resistance, beta-lactamase, antibiotic, hydrolase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39616.49

構造登録者

Brem, J.,Cahill, S.T.,McDonough, M.A.,Schofield, C.J. (登録日: 2018-11-02, 公開日: 2019-02-20, 最終更新日: 2024-11-20)

主引用文献

Cahill, S.T.,Tyrrell, J.M.,Navratilova, I.H.,Calvopina, K.,Robinson, S.W.,Lohans, C.T.,McDonough, M.A.,Cain, R.,Fishwick, C.W.G.,Avison, M.B.,Walsh, T.R.,Schofield, C.J.,Brem, J.
Studies on the inhibition of AmpC and other beta-lactamases by cyclic boronates.
Biochim Biophys Acta Gen Subj, 1863:742-748, 2019

PubMed Abstract: The β-lactam antibiotics represent the most successful drug class for treatment of bacterial infections. Resistance to them, importantly via production of β-lactamases, which collectively are able to hydrolyse all classes of β-lactams, threatens their continued widespread use. Bicyclic boronates show potential as broad spectrum inhibitors of the mechanistically distinct serine- (SBL) and metallo- (MBL) β-lactamase families.

PubMed: 30738906
DOI: 10.1016/j.bbagen.2019.02.004

実験手法

X-RAY DIFFRACTION (2.21 Å)