6I28

Crystal Structure of Cydia Pomonella PTP-2 phosphatase

6I28 の概要

• エントリーDOI: 10.2210/pdb6i28/pdb
• 分子名称: ORF98 PTP-2, GLYCEROL, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: cydia pomonella, ptp-2 phosphatase, viral protein
• 由来する生物種: Cydia pomonella granulosis virus (CpGV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19610.48

構造登録者

Huang, G.,Keown, J.P.,Oliver, M.R.,Metcalf, P. (登録日: 2018-10-31, 公開日: 2019-02-20, 最終更新日: 2024-05-15)

主引用文献

Huang, G.,Oliver, M.R.,Keown, J.R.,Goldstone, D.C.,Metcalf, P.
Crystal structure of protein tyrosine phosphatase-2 from Cydia pomonella granulovirus.
Acta Crystallogr.,Sect.F, 75:233-238, 2019

PubMed Abstract: Many viral genomes encode kinase and phosphatase enzymes to manipulate pathways that are controlled by phosphorylation events. The majority of viral phosphatase genes occur in the Baculoviridae and Poxviridae families of large DNA viruses. The corresponding protein sequences belong to four major homology groups, and structures are currently available for only two of these. Here, the first structure from the third group, the protein tyrosine phosphatase-2 (PTP-2) class of viral phosphatases, is described. It is shown that Cydia pomonella granulovirus PTP-2 has the same general fold and active-site architecture as described previously for other phosphatases, in the absence of significant sequence homology. Additionally, it has a novel C-terminal extension in an area corresponding to the interface of dimeric poxvirus phosphatases belonging to the Tyr-Ser protein phosphatase homology group.

PubMed: 30950823
DOI: 10.1107/S2053230X19002322

実験手法

X-RAY DIFFRACTION (1.65 Å)