6I17

CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 24

6I17 の概要

• エントリーDOI: 10.2210/pdb6i17/pdb
• 分子名称: Fascin, ACETATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: actin bundling, small molecule inhibition, structural protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55234.39

構造登録者

Schuettelkopf, A.W. (登録日: 2018-10-27, 公開日: 2019-02-27, 最終更新日: 2024-01-24)

• 主引用文献: Francis, S.,Croft, D.,Schuttelkopf, A.W.,Parry, C.,Pugliese, A.,Cameron, K.,Claydon, S.,Drysdale, M.,Gardner, C.,Gohlke, A.,Goodwin, G.,Gray, C.H.,Konczal, J.,McDonald, L.,Mezna, M.,Pannifer, A.,Paul, N.R.,Machesky, L.,McKinnon, H.,Bower, J.; Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.; Bioorg.Med.Chem.Lett., 29:1023-1029, 2019; PubMed: 30773430; DOI: 10.1016/j.bmcl.2019.01.035

実験手法

X-RAY DIFFRACTION (1.56 Å)