6I15

CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 11

Summary for 6I15

Entry DOI	10.2210/pdb6i15/pdb
Descriptor	Fascin, 1,2-ETHANEDIOL, ACETATE ION, ... (5 entities in total)
Functional Keywords	actin bundling, small molecule inhibition, structural protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	55107.32
Authors	Schuettelkopf, A.W. (deposition date: 2018-10-27, release date: 2019-02-27, Last modification date: 2024-01-24)
Primary citation	Francis, S.,Croft, D.,Schuttelkopf, A.W.,Parry, C.,Pugliese, A.,Cameron, K.,Claydon, S.,Drysdale, M.,Gardner, C.,Gohlke, A.,Goodwin, G.,Gray, C.H.,Konczal, J.,McDonald, L.,Mezna, M.,Pannifer, A.,Paul, N.R.,Machesky, L.,McKinnon, H.,Bower, J. Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29:1023-1029, 2019 Cited by PubMed: 30773430 DOI: 10.1016/j.bmcl.2019.01.035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation