6I0P

Structure of quinolinate synthase in complex with 6-mercaptopyridine-2,3-dicarboxylic acid

Summary for 6I0P

Entry DOI	10.2210/pdb6i0p/pdb
Related	6I0K
Descriptor	Quinolinate synthase A, IRON/SULFUR CLUSTER, 6-mercaptopyridine-2,3-dicarboxylic acid, ... (6 entities in total)
Functional Keywords	nad biosynthesis, iron sulfur cluster, transferase
Biological source	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Total number of polymer chains	1
Total formula weight	35321.85
Authors	Volbeda, A.,Fontecilla-Camps, J.C. (deposition date: 2018-10-26, release date: 2019-03-20, Last modification date: 2024-01-24)
Primary citation	Saez Cabodevilla, J.,Volbeda, A.,Hamelin, O.,Latour, J.M.,Gigarel, O.,Clemancey, M.,Darnault, C.,Reichmann, D.,Amara, P.,Fontecilla-Camps, J.C.,Ollagnier de Choudens, S. Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination. Chem.Commun.(Camb.), 55:3725-3728, 2019 Cited by PubMed Abstract: Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme. PubMed: 30855610 DOI: 10.1039/c8cc09023h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation