6I0P

Structure of quinolinate synthase in complex with 6-mercaptopyridine-2,3-dicarboxylic acid

6I0P の概要

• エントリーDOI: 10.2210/pdb6i0p/pdb
• 関連するPDBエントリー: 6I0K
• 分子名称: Quinolinate synthase A, IRON/SULFUR CLUSTER, 6-mercaptopyridine-2,3-dicarboxylic acid, ... (6 entities in total)
• 機能のキーワード: nad biosynthesis, iron sulfur cluster, transferase
• 由来する生物種: Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35321.85

構造登録者

Volbeda, A.,Fontecilla-Camps, J.C. (登録日: 2018-10-26, 公開日: 2019-03-20, 最終更新日: 2024-01-24)

主引用文献

Saez Cabodevilla, J.,Volbeda, A.,Hamelin, O.,Latour, J.M.,Gigarel, O.,Clemancey, M.,Darnault, C.,Reichmann, D.,Amara, P.,Fontecilla-Camps, J.C.,Ollagnier de Choudens, S.
Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.
Chem.Commun.(Camb.), 55:3725-3728, 2019

PubMed Abstract: Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme.

PubMed: 30855610
DOI: 10.1039/c8cc09023h

実験手法

X-RAY DIFFRACTION (1.9 Å)