6HZB
X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-Arg-Arg-Lys]-Lys-4-Amba
Summary for 6HZB
Entry DOI | 10.2210/pdb6hzb/pdb |
Descriptor | Furin, ARG-ARG-LYS-LYS-00S, CALCIUM ION, ... (9 entities in total) |
Functional Keywords | protease, proprotein convertase, inhibitor complex, cyclic peptide, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 53703.39 |
Authors | Dahms, S.O. (deposition date: 2018-10-23, release date: 2019-02-06, Last modification date: 2024-01-24) |
Primary citation | Van Lam van, T.,Ivanova, T.,Hardes, K.,Heindl, M.R.,Morty, R.E.,Bottcher-Friebertshauser, E.,Lindberg, I.,Than, M.E.,Dahms, S.O.,Steinmetzer, T. Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14:673-685, 2019 Cited by PubMed: 30680958DOI: 10.1002/cmdc.201800807 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report