6HX1

IRE1 ALPHA IN COMPLEX WITH imidazo[1,2-b]pyridazin-8-amine compound 2

Summary for 6HX1

Entry DOI	10.2210/pdb6hx1/pdb
Descriptor	Serine/threonine-protein kinase/endoribonuclease IRE1, 6-chloranyl-~{N}-(cyclopropylmethyl)-3-(2~{H}-indazol-5-yl)imidazo[1,2-b]pyridazin-8-amine (3 entities in total)
Functional Keywords	ire1 kinase, proteros biostructures gmbh, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	46755.14
Authors	Augustin, M.A.,Krapp, S.,Bayliss, R.,Collins, I. (deposition date: 2018-10-15, release date: 2019-02-27, Last modification date: 2024-01-24)
Primary citation	Colombano, G.,Caldwell, J.J.,Matthews, T.P.,Bhatia, C.,Joshi, A.,McHardy, T.,Mok, N.Y.,Newbatt, Y.,Pickard, L.,Strover, J.,Hedayat, S.,Walton, M.I.,Myers, S.M.,Jones, A.M.,Saville, H.,McAndrew, C.,Burke, R.,Eccles, S.A.,Davies, F.E.,Bayliss, R.,Collins, I. Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 alpha Kinase-Endoribonuclease. J.Med.Chem., 62:2447-2465, 2019 Cited by PubMed: 30779566 DOI: 10.1021/acs.jmedchem.8b01721 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation