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6HWV

Crystal structure of p38alpha in complex with a photoswitchable 2-Azoimidazol-based Inhibitor (compound 3)

Summary for 6HWV
Entry DOI10.2210/pdb6hwv/pdb
DescriptorMitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 3-(2,5-dimethoxyphenyl)-~{N}-[4-[5-(4-fluorophenyl)-2-[(~{E})-(4-fluorophenyl)diazenyl]-3-methyl-imidazol-4-yl]pyridin-2-yl]propanamide, ... (4 entities in total)
Functional Keywordsp38alpha, mapk14, photoswitchable, azothiazol, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight42953.98
Authors
Mueller, M.P.,Rauh, D. (deposition date: 2018-10-15, release date: 2019-04-17, Last modification date: 2024-01-24)
Primary citationSchehr, M.,Ianes, C.,Weisner, J.,Heintze, L.,Muller, M.P.,Pichlo, C.,Charl, J.,Brunstein, E.,Ewert, J.,Lehr, M.,Baumann, U.,Rauh, D.,Knippschild, U.,Peifer, C.,Herges, R.
2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach.
Photochem. Photobiol. Sci., 18:1398-1407, 2019
Cited by
PubMed: 30924488
DOI: 10.1039/c9pp00010k
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

數據於2024-03-27公開中

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