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6HV0

IRE1 kinase/RNase in complex with imidazo[1,2-b]pyridazin-8-amine compound 33

Summary for 6HV0
Entry DOI10.2210/pdb6hv0/pdb
DescriptorSerine/threonine-protein kinase/endoribonuclease IRE1, 6-chloranyl-3-(2~{H}-indazol-5-yl)-~{N}-propan-2-yl-imidazo[1,2-b]pyridazin-8-amine (3 entities in total)
Functional Keywordsunfolded protein response allosteric inhibitor, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight48082.60
Authors
Bayliss, R.,Bhatia, C.,Collins, I. (deposition date: 2018-10-09, release date: 2019-02-27, Last modification date: 2024-01-24)
Primary citationColombano, G.,Caldwell, J.J.,Matthews, T.P.,Bhatia, C.,Joshi, A.,McHardy, T.,Mok, N.Y.,Newbatt, Y.,Pickard, L.,Strover, J.,Hedayat, S.,Walton, M.I.,Myers, S.M.,Jones, A.M.,Saville, H.,McAndrew, C.,Burke, R.,Eccles, S.A.,Davies, F.E.,Bayliss, R.,Collins, I.
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 alpha Kinase-Endoribonuclease.
J.Med.Chem., 62:2447-2465, 2019
Cited by
PubMed: 30779566
DOI: 10.1021/acs.jmedchem.8b01721
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.73 Å)
Structure validation

217705

건을2024-03-27부터공개중

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