6HV0

IRE1 kinase/RNase in complex with imidazo[1,2-b]pyridazin-8-amine compound 33

6HV0 の概要

• エントリーDOI: 10.2210/pdb6hv0/pdb
• 分子名称: Serine/threonine-protein kinase/endoribonuclease IRE1, 6-chloranyl-3-(2~{H}-indazol-5-yl)-~{N}-propan-2-yl-imidazo[1,2-b]pyridazin-8-amine (3 entities in total)
• 機能のキーワード: unfolded protein response allosteric inhibitor, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48082.60

構造登録者

Bayliss, R.,Bhatia, C.,Collins, I. (登録日: 2018-10-09, 公開日: 2019-02-27, 最終更新日: 2024-01-24)

• 主引用文献: Colombano, G.,Caldwell, J.J.,Matthews, T.P.,Bhatia, C.,Joshi, A.,McHardy, T.,Mok, N.Y.,Newbatt, Y.,Pickard, L.,Strover, J.,Hedayat, S.,Walton, M.I.,Myers, S.M.,Jones, A.M.,Saville, H.,McAndrew, C.,Burke, R.,Eccles, S.A.,Davies, F.E.,Bayliss, R.,Collins, I.; Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 alpha Kinase-Endoribonuclease.; J.Med.Chem., 62:2447-2465, 2019; PubMed: 30779566; DOI: 10.1021/acs.jmedchem.8b01721

実験手法

X-RAY DIFFRACTION (2.73 Å)