6HT1

Crystal structure of MLLT1 (ENL) YEATS domain in complexed with SGC-iMLLT (compound 92)

Summary for 6HT1

Related6HT0
DescriptorProtein ENL, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordstranscription, yeats domain, enl, mllt1, chemical probe, inhibitor, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight19327.15
Authors
Heidenreich, D.,Chaikuad, A.,Moustakim, M.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Fedorov, O.,Brennan, P.E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-10-02, release date: 2018-10-17, Last modification date: 2018-12-12)
Primary citation
Moustakim, M.,Christott, T.,Monteiro, O.P.,Bennett, J.,Giroud, C.,Ward, J.,Rogers, C.M.,Smith, P.,Panagakou, I.,Diaz-Saez, L.,Felce, S.L.,Gamble, V.,Gileadi, C.,Halidi, N.,Heidenreich, D.,Chaikuad, A.,Knapp, S.,Huber, K.V.M.,Farnie, G.,Heer, J.,Manevski, N.,Poda, G.,Al-Awar, R.,Dixon, D.J.,Brennan, P.E.,Fedorov, O.
Discovery of an MLLT1/3 YEATS Domain Chemical Probe.
Angew. Chem. Int. Ed. Engl., 57:16302-16307, 2018
PubMed: 30288907 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201810617
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.265600 3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution