6HSG

Crystal structure of Schistosoma mansoni HDAC8 H292M mutant complexed with NCC-149

6HSG の概要

• エントリーDOI: 10.2210/pdb6hsg/pdb
• 分子名称: Histone deacetylase, ZINC ION, POTASSIUM ION, ... (7 entities in total)
• 機能のキーワード: epigenetics, histone deacetylase, hdac8, selective inhibitor, pathogen, hydrolase
• 由来する生物種: Schistosoma mansoni (Blood fluke)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 206071.48

構造登録者

Shaik, T.B.,Marek, M.,Romier, C. (登録日: 2018-10-01, 公開日: 2018-10-31, 最終更新日: 2018-11-28)

• 主引用文献: Marek, M.,Shaik, T.B.,Heimburg, T.,Chakrabarti, A.,Lancelot, J.,Ramos-Morales, E.,Da Veiga, C.,Kalinin, D.,Melesina, J.,Robaa, D.,Schmidtkunz, K.,Suzuki, T.,Holl, R.,Ennifar, E.,Pierce, R.J.,Jung, M.,Sippl, W.,Romier, C.; Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.; J. Med. Chem., 61:10000-10016, 2018; PubMed: 30347148; DOI: 10.1021/acs.jmedchem.8b01087

実験手法

X-RAY DIFFRACTION (1.846 Å)