6HS4

Crystal structure of Ebolavirus glycoprotein in complex with inhibitor 118

6HS4 の概要

• エントリーDOI: 10.2210/pdb6hs4/pdb
• 分子名称: Envelope glycoprotein,GP1,Envelope glycoprotein, Envelope glycoprotein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: ebola glycoprotein, structure-based in silico screening, compound 118, compound 118a, natural compound, viral protein
• 由来する生物種: Zaire ebolavirus (strain Mayinga-76) (ZEBOV); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58494.38

構造登録者

Ren, J.,Zhao, Y.,Stuart, D.I. (登録日: 2018-09-28, 公開日: 2019-02-27, 最終更新日: 2024-01-24)

• 主引用文献: Shaikh, F.,Zhao, Y.,Alvarez, L.,Iliopoulou, M.,Lohans, C.,Schofield, C.J.,Padilla-Parra, S.,Siu, S.W.I.,Fry, E.E.,Ren, J.,Stuart, D.I.; Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library.; J.Med.Chem., 62:2928-2937, 2019; PubMed: 30785281; DOI: 10.1021/acs.jmedchem.8b01328

実験手法

X-RAY DIFFRACTION (2.05 Å)