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6HPY

Crystal structure of ENL (MLLT1) in complex with compound 12

Summary for 6HPY
Entry DOI10.2210/pdb6hpy/pdb
Related6HPW 6HPX 6HPZ 6HQ0
DescriptorProtein ENL, 1,2-ETHANEDIOL, SULFATE ION, ... (5 entities in total)
Functional Keywordsyeats domain, inhibitor complex, structural genomics, structural genomics consortium, sgc, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight18919.75
Authors
Heidenreich, D.,Chaikuad, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-09-22, release date: 2018-11-28, Last modification date: 2024-01-24)
Primary citationHeidenreich, D.,Moustakim, M.,Schmidt, J.,Merk, D.,Brennan, P.E.,Fedorov, O.,Chaikuad, A.,Knapp, S.
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
J.Med.Chem., 61:10929-10934, 2018
Cited by
PubMed: 30407816
DOI: 10.1021/acs.jmedchem.8b01457
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

數據於2024-03-27公開中

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