6HPW

Crystal structure of ENL (MLLT1) in complex with compound 20

Summary for 6HPW

Entry DOI	10.2210/pdb6hpw/pdb
Related	6HPX 6HPY 6HPZ 6HQ0
Descriptor	Protein ENL, 1,2-ETHANEDIOL, 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide, ... (4 entities in total)
Functional Keywords	yeats domain, inhibitor complex, structural genomics, structural genomics consortium, sgc, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	19282.96
Authors	Heidenreich, D.,Chaikuad, A.,Moustakim, M.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-09-22, release date: 2018-11-28, Last modification date: 2024-01-24)
Primary citation	Heidenreich, D.,Moustakim, M.,Schmidt, J.,Merk, D.,Brennan, P.E.,Fedorov, O.,Chaikuad, A.,Knapp, S. Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). J.Med.Chem., 61:10929-10934, 2018 Cited by PubMed: 30407816 DOI: 10.1021/acs.jmedchem.8b01457 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation