6HMN

POLYADPRIBOSYL GLYCOSIDASE IN COMPLEX WITH PDD00014909

6HMN の概要

• エントリーDOI: 10.2210/pdb6hmn/pdb
• 分子名称: Poly(ADP-ribose) glycohydrolase, DIMETHYL SULFOXIDE, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: hydrolase, competitive inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61708.09

構造登録者

Tucker, J.A.,Brassington, C.,Hassall, G. (登録日: 2018-09-12, 公開日: 2018-11-14, 最終更新日: 2024-01-24)

• 主引用文献: Waszkowycz, B.,Smith, K.M.,McGonagle, A.E.,Jordan, A.M.,Acton, B.,Fairweather, E.E.,Griffiths, L.A.,Hamilton, N.M.,Hamilton, N.S.,Hitchin, J.R.,Hutton, C.P.,James, D.I.,Jones, C.D.,Jones, S.,Mould, D.P.,Small, H.F.,Stowell, A.I.J.,Tucker, J.A.,Waddell, I.D.,Ogilvie, D.J.; Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.; J.Med.Chem., 61:10767-10792, 2018; PubMed: 30403352; DOI: 10.1021/acs.jmedchem.8b01407

実験手法

X-RAY DIFFRACTION (2.87 Å)