6HKN

Crystal structure of Compound 35 with ERK5

Summary for 6HKN

Entry DOI	10.2210/pdb6hkn/pdb
Descriptor	Mitogen-activated protein kinase 7, [2-azanyl-4-(trifluoromethyloxy)phenyl]-[4-(7-methoxyquinazolin-4-yl)piperidin-1-yl]methanone (3 entities in total)
Functional Keywords	erk5 kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	39468.43
Authors	Nguyen, D.,Lemos, C.,Wortmann, L.,Eis, K.,Holton, S.J.,Boemer, U.,Lechner, C.,Prechtl, S.,Suelze, D.,Siegel, F.,Prinz, F.,Lesche, R.,Nicke, B.,Mumberg, D.,Bauser, M.,Haegebarth, A. (deposition date: 2018-09-07, release date: 2019-02-27)
Primary citation	Nguyen, D.,Lemos, C.,Wortmann, L.,Eis, K.,Holton, S.J.,Boemer, U.,Moosmayer, D.,Eberspaecher, U.,Weiske, J.,Lechner, C.,Prechtl, S.,Suelzle, D.,Siegel, F.,Prinz, F.,Lesche, R.,Nicke, B.,Nowak-Reppel, K.,Himmel, H.,Mumberg, D.,von Nussbaum, F.,Nising, C.F.,Bauser, M.,Haegebarth, A. Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J. Med. Chem., 62:928-940, 2019 Cited by PubMed: 30563338 DOI: 10.1021/acs.jmedchem.8b01606 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation