6HJJ

Crystal structure of Aurora-A L210C catalytic domain in complex with ASDO6 ligand

6HJJ の概要

• エントリーDOI: 10.2210/pdb6hjj/pdb
• 分子名称: Aurora kinase A, ~{N}-[4-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-3-methyl-phenyl]-4-[4-fluoranyl-3-(trifluoromethyl)phenyl]-4-oxidanylidene-butanamide, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: protein kinase, mitosis, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33878.89

構造登録者

Bayliss, R.,McIntyre, P.J. (登録日: 2018-09-04, 公開日: 2018-10-03, 最終更新日: 2018-10-31)

• 主引用文献: Ocasio, C.A.,Warkentin, A.A.,McIntyre, P.J.,Barkovich, K.J.,Vesely, C.,Spencer, J.,Shokat, K.M.,Bayliss, R.; Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases.; ACS Chem. Biol., 13:2956-2965, 2018; PubMed: 30239186; DOI: 10.1021/acschembio.8b00592

実験手法

X-RAY DIFFRACTION (2.13 Å)