6HIE

The ATAD2 bromodomain in complex with compound 17

Summary for 6HIE

Entry DOI	10.2210/pdb6hie/pdb
Descriptor	ATPase family AAA domain-containing protein 2, (2~{R})-1-[2-[4,4-bis(fluoranyl)cyclohexyl]ethyl]-~{N}-(4-ethanoyl-1,3-thiazol-2-yl)piperazine-2-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	bromodomain, atad2, inhibitor, complex, cytosolic protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15950.06
Authors	Sledz, P.,Caflisch, A. (deposition date: 2018-08-29, release date: 2019-02-20, Last modification date: 2024-01-17)
Primary citation	Dolbois, A.,Batiste, L.,Wiedmer, L.,Dong, J.,Brutsch, M.,Huang, D.,Deerain, N.M.,Spiliotopoulos, D.,Cheng-Sanchez, I.,Laul, E.,Nevado, C.,Sledz, P.,Caflisch, A. Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers. Acs Med.Chem.Lett., 11:1573-1580, 2020 Cited by PubMed: 32832026 DOI: 10.1021/acsmedchemlett.0c00080 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation