6HE2
Crystal structure of an open conformation of 2-Hydroxyisobutyryl-CoA Ligase (HCL) in complex with 2-HIB-AMP and CoA
Summary for 6HE2
Entry DOI | 10.2210/pdb6he2/pdb |
Descriptor | 2-hydroxyisobutyryl-CoA synthetase, ADENOSINE MONOPHOSPHATE, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] 2-methyl-2-oxidanyl-propanoate, ... (5 entities in total) |
Functional Keywords | ligase, 2-hydroxyisobutyrate coa |
Biological source | Aquincola tertiaricarbonis |
Total number of polymer chains | 2 |
Total formula weight | 114982.25 |
Authors | Zahn, M.,Rohwerder, T.,Strater, N. (deposition date: 2018-08-20, release date: 2019-08-28, Last modification date: 2024-01-17) |
Primary citation | Zahn, M.,Kurteva-Yaneva, N.,Schuster, J.,Krug, U.,Georgi, T.,Muller, R.H.,Rohwerder, T.,Strater, N. Structures of 2-Hydroxyisobutyric Acid-CoA Ligase Reveal Determinants of Substrate Specificity and Describe a Multi-Conformational Catalytic Cycle. J.Mol.Biol., 431:2747-2761, 2019 Cited by PubMed: 31145912DOI: 10.1016/j.jmb.2019.05.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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