6HE2

Crystal structure of an open conformation of 2-Hydroxyisobutyryl-CoA Ligase (HCL) in complex with 2-HIB-AMP and CoA

6HE2 の概要

• エントリーDOI: 10.2210/pdb6he2/pdb
• 分子名称: 2-hydroxyisobutyryl-CoA synthetase, ADENOSINE MONOPHOSPHATE, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] 2-methyl-2-oxidanyl-propanoate, ... (5 entities in total)
• 機能のキーワード: ligase, 2-hydroxyisobutyrate coa
• 由来する生物種: Aquincola tertiaricarbonis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114982.25

構造登録者

Zahn, M.,Rohwerder, T.,Strater, N. (登録日: 2018-08-20, 公開日: 2019-08-28, 最終更新日: 2024-01-17)

• 主引用文献: Zahn, M.,Kurteva-Yaneva, N.,Schuster, J.,Krug, U.,Georgi, T.,Muller, R.H.,Rohwerder, T.,Strater, N.; Structures of 2-Hydroxyisobutyric Acid-CoA Ligase Reveal Determinants of Substrate Specificity and Describe a Multi-Conformational Catalytic Cycle.; J.Mol.Biol., 431:2747-2761, 2019; PubMed: 31145912; DOI: 10.1016/j.jmb.2019.05.027

実験手法

X-RAY DIFFRACTION (2.3 Å)