6HCW

Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and a difluoro cyclohexyl chromone ligand

6HCW の概要

• エントリーDOI: 10.2210/pdb6hcw/pdb
• 分子名称: Lysine--tRNA ligase, LYSINE, ~{N}-[[4,4-bis(fluoranyl)-1-oxidanyl-cyclohexyl]methyl]-6-fluoranyl-4-oxidanylidene-chromene-2-carboxamide, ... (5 entities in total)
• 機能のキーワード: adenylyltransferase activity, trna binding, ligase, transferase
• 由来する生物種: Cryptosporidium parvum (strain Iowa II)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 124045.34

構造登録者

Robinson, D.A.,Baragana, B.,Norcross, N.,Forte, B.,Walpole, C.,Gilbert, I.H. (登録日: 2018-08-16, 公開日: 2019-04-03, 最終更新日: 2024-01-17)

• 主引用文献: Baragana, B.,Forte, B.,Choi, R.,Nakazawa Hewitt, S.,Bueren-Calabuig, J.A.,Pisco, J.P.,Peet, C.,Dranow, D.M.,Robinson, D.A.,Jansen, C.,Norcross, N.R.,Vinayak, S.,Anderson, M.,Brooks, C.F.,Cooper, C.A.,Damerow, S.,Delves, M.,Dowers, K.,Duffy, J.,Edwards, T.E.,Hallyburton, I.,Horst, B.G.,Hulverson, M.A.,Ferguson, L.,Jimenez-Diaz, M.B.,Jumani, R.S.,Lorimer, D.D.,Love, M.S.,Maher, S.,Matthews, H.,McNamara, C.W.,Miller, P.,O'Neill, S.,Ojo, K.K.,Osuna-Cabello, M.,Pinto, E.,Post, J.,Riley, J.,Rottmann, M.,Sanz, L.M.,Scullion, P.,Sharma, A.,Shepherd, S.M.,Shishikura, Y.,Simeons, F.R.C.,Stebbins, E.E.,Stojanovski, L.,Straschil, U.,Tamaki, F.K.,Tamjar, J.,Torrie, L.S.,Vantaux, A.,Witkowski, B.,Wittlin, S.,Yogavel, M.,Zuccotto, F.,Angulo-Barturen, I.,Sinden, R.,Baum, J.,Gamo, F.J.,Maser, P.,Kyle, D.E.,Winzeler, E.A.,Myler, P.J.,Wyatt, P.G.,Floyd, D.,Matthews, D.,Sharma, A.,Striepen, B.,Huston, C.D.,Gray, D.W.,Fairlamb, A.H.,Pisliakov, A.V.,Walpole, C.,Read, K.D.,Van Voorhis, W.C.,Gilbert, I.H.; Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.; Proc.Natl.Acad.Sci.USA, 116:7015-7020, 2019; PubMed: 30894487; DOI: 10.1073/pnas.1814685116

実験手法

X-RAY DIFFRACTION (1.46 Å)