6HCD

Structure of universal stress protein from Archaeoglobus fulgidus

「3DLO」から置き換えられました

6HCD の概要

• エントリーDOI: 10.2210/pdb6hcd/pdb
• 関連するPDBエントリー: 2PFS 3QTB 3TNJ
• 分子名称: UNIVERSAL STRESS PROTEIN, UNKNOWN LIGAND, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: unknown function, structural genomics, psi-2, protein structure, protein structure initiative, midwest center for structural genomics, mcsg, nuclear protein
• 由来する生物種: Archaeoglobus fulgidus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 70511.86

構造登録者

Shumilin, I.A.,Loch, J.I.,Cymborowski, M.,Xu, X.,Edwards, A.,Di Leo, R.,Shabalin, I.G.,Joachimiak, A.,Savchenko, A.,Minor, W.,Midwest Center for Structural Genomics (MCSG) (登録日: 2018-08-14, 公開日: 2018-08-29, 最終更新日: 2024-10-16)

主引用文献

Tkaczuk, K.L.,A Shumilin, I.,Chruszcz, M.,Evdokimova, E.,Savchenko, A.,Minor, W.
Structural and functional insight into the universal stress protein family.
Evol Appl, 6:434-449, 2013

PubMed Abstract: We present the crystal structures of two universal stress proteins (USP) from Archaeoglobus fulgidus and Nitrosomonas europaea in both apo- and ligand-bound forms. This work is the first complete synthesis of the structural properties of 26 USP available in the Protein Data Bank, over 75% of which were determined by structure genomics centers with no additional information provided. The results of bioinformatic analyses of all available USP structures and their sequence homologs revealed that these two new USP structures share overall structural similarity with structures of USPs previously determined. Clustering and cladogram analyses, however, show how they diverge from other members of the USP superfamily and show greater similarity to USPs from organisms inhabiting extreme environments. We compared them with other archaeal and bacterial USPs and discuss their similarities and differences in context of structure, sequential motifs, and potential function. We also attempted to group all analyzed USPs into families, so that assignment of the potential function to those with no experimental data available would be possible by extrapolation.

PubMed: 23745136
DOI: 10.1111/eva.12057

実験手法

X-RAY DIFFRACTION (1.9 Å)