6HBU
Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and Magnesium
Summary for 6HBU
| Entry DOI | 10.2210/pdb6hbu/pdb |
| EMDB information | 0190 |
| Descriptor | ATP-binding cassette sub-family G member 2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION (3 entities in total) |
| Functional Keywords | multidrug transporter, membrane protein, cancer |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 145832.71 |
| Authors | Manolaridis, I.,Jackson, S.M.,Taylor, N.M.I.,Kowal, J.,Stahlberg, H.,Locher, K.P. (deposition date: 2018-08-13, release date: 2018-11-07, Last modification date: 2019-10-23) |
| Primary citation | Manolaridis, I.,Jackson, S.M.,Taylor, N.M.I.,Kowal, J.,Stahlberg, H.,Locher, K.P. Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature, 563:426-430, 2018 Cited by PubMed: 30405239DOI: 10.1038/s41586-018-0680-3 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.09 Å) |
Structure validation
Download full validation report
