6HB5

Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-cytidine

6HB5 の概要

関連するPDBエントリー6HB7 6HB6
分子名称Tyrosine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate, 1,2-ETHANEDIOL, ... (5 entities in total)
機能のキーワードprotein-inhibitor complex, rossmann fold, trna aminoacylation, ligase
由来する生物種Escherichia coli (strain B / BL21-DE3)
ポリマー鎖数2
分子量合計96382.26
構造登録者
De Graef, S.,Pang, L.,Strelkov, S.V.,Weeks, S.D. (登録日: 2018-08-09, 公開日: 2019-04-17, 最終更新日: 2019-05-01)
主引用文献
Nautiyal, M.,De Graef, S.,Pang, L.,Gadakh, B.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A.
Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173:154-166, 2019
PubMed: 30995568 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.ejmech.2019.04.003
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.88 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22310 1.3% 2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード

他の静止画像(非対称単位)

Molmil generated image of 6hb5
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Molmil generated image of 6hb5
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Molmil generated image of 6hb5
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