6H5W

Crystal structure of human Angiotensin-1 converting enzyme C-domain in complex with Omapatrilat.

6H5W の概要

• エントリーDOI: 10.2210/pdb6h5w/pdb
• 分子名称: Angiotensin-converting enzyme, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: angiotensin-1 converting enzyme, ace inhibitor, omapatrilat, vasopeptidase inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 71725.56

構造登録者

Cozier, G.E.,Acharya, K.R. (登録日: 2018-07-25, 公開日: 2018-11-07, 最終更新日: 2024-01-17)

• 主引用文献: Cozier, G.E.,Arendse, L.B.,Schwager, S.L.,Sturrock, E.D.,Acharya, K.R.; Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.; J. Med. Chem., 61:10141-10154, 2018; PubMed: 30372620; DOI: 10.1021/acs.jmedchem.8b01309

実験手法

X-RAY DIFFRACTION (1.37 Å)