6H5G

Crystal structure of DHQ1 from Salmonella typhi covalently modified by ligand 3

6H5G の概要

• エントリーDOI: 10.2210/pdb6h5g/pdb
• 分子名称: 3-dehydroquinate dehydratase, (1~{R},3~{S},4~{R},5~{R})-3-methyl-4,5-bis(hydroxyl)cyclohexane-1-carboxylic acid (3 entities in total)
• 機能のキーワード: lyase activity, chorismate biosynthetic process, 3-dehydroquinase, covalent inhibitor, lyase
• 由来する生物種: Salmonella enterica subsp. enterica serovar Typhi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27855.19

構造登録者

Sanz-Gaitero, M.,Maneiro, M.,Lence, E.,Otero, J.M.,Thompson, P.,Hawkins, A.R.,Gonzalez-Bello, C.,van Raaij, M.J. (登録日: 2018-07-24, 公開日: 2019-07-24, 最終更新日: 2024-01-17)

• 主引用文献: Maneiro, M.,Lence, E.,Sanz-Gaitero, M.,Otero, J.M.,van Raaij, M.J.,Thompson, P.,Hawkins, A.R.,Gonzalez-Bello, C.; Hydroxylammonium Derivatives for Selective Active-site Lysine Modification in the Anti-virulence Bacterial Target DHQ1 Enzyme.; Org Chem Front, 6:3127-3135, 2019; DOI: 10.1039/c9qo00453j

実験手法

X-RAY DIFFRACTION (1.04 Å)