6H4W
Crystal structure of human KDM4A in complex with compound 19d
6H4W の概要
エントリーDOI | 10.2210/pdb6h4w/pdb |
分子名称 | Lysine-specific demethylase 4A, ZINC ION, 8-[4-[2-[4-(3-chlorophenyl)-4-methyl-piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ... (6 entities in total) |
機能のキーワード | histone demethylase, inhibitor, transcription, oxidoreductase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 170085.52 |
構造登録者 | |
主引用文献 | Le Bihan, Y.V.,Lanigan, R.M.,Atrash, B.,McLaughlin, M.G.,Velupillai, S.,Malcolm, A.G.,England, K.S.,Ruda, G.F.,Mok, N.Y.,Tumber, A.,Tomlin, K.,Saville, H.,Shehu, E.,McAndrew, C.,Carmichael, L.,Bennett, J.M.,Jeganathan, F.,Eve, P.,Donovan, A.,Hayes, A.,Wood, F.,Raynaud, F.I.,Fedorov, O.,Brennan, P.E.,Burke, R.,van Montfort, R.L.M.,Rossanese, O.W.,Blagg, J.,Bavetsias, V. C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur.J.Med.Chem., 177:316-337, 2019 Cited by PubMed: 31158747DOI: 10.1016/j.ejmech.2019.05.041 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.81 Å) |
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