6H4U

Crystal structure of human KDM4A in complex with compound 34b

6H4U の概要

• エントリーDOI: 10.2210/pdb6h4u/pdb
• 分子名称: Lysine-specific demethylase 4A, ZINC ION, 8-[4-(1-methylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ... (7 entities in total)
• 機能のキーワード: histone demethylase, inhibitor, transcription, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 169899.82

構造登録者

Le Bihan, Y.V.,van Montfort, R.L.M. (登録日: 2018-07-23, 公開日: 2019-06-12, 最終更新日: 2024-01-17)

• 主引用文献: Le Bihan, Y.V.,Lanigan, R.M.,Atrash, B.,McLaughlin, M.G.,Velupillai, S.,Malcolm, A.G.,England, K.S.,Ruda, G.F.,Mok, N.Y.,Tumber, A.,Tomlin, K.,Saville, H.,Shehu, E.,McAndrew, C.,Carmichael, L.,Bennett, J.M.,Jeganathan, F.,Eve, P.,Donovan, A.,Hayes, A.,Wood, F.,Raynaud, F.I.,Fedorov, O.,Brennan, P.E.,Burke, R.,van Montfort, R.L.M.,Rossanese, O.W.,Blagg, J.,Bavetsias, V.; C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.; Eur.J.Med.Chem., 177:316-337, 2019; PubMed: 31158747; DOI: 10.1016/j.ejmech.2019.05.041

実験手法

X-RAY DIFFRACTION (2.21 Å)