6H3Q
Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide
Summary for 6H3Q
Entry DOI | 10.2210/pdb6h3q/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29690.14 |
Authors | Ferraroni, M.,Angeli, A.,Supuran, C. (deposition date: 2018-07-19, release date: 2019-07-17, Last modification date: 2024-01-17) |
Primary citation | Angeli, A.,Trallori, E.,Ferraroni, M.,Di Cesare Mannelli, L.,Ghelardini, C.,Supuran, C.T. Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity. Eur.J.Med.Chem., 157:1214-1222, 2018 Cited by PubMed: 30193219DOI: 10.1016/j.ejmech.2018.08.096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.31 Å) |
Structure validation
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