6H1X

Receptor-binding domain of Proteus mirabilis Uroepithelial Cell Adhesin UcaD21-211

6H1X の概要

• エントリーDOI: 10.2210/pdb6h1x/pdb
• 分子名称: Putative fimbrial adhesin, COBALT (II) ION (3 entities in total)
• 機能のキーワード: fimbriae, adhesin, proteus mirabilis, urinary tract infection, cell adhesion
• 由来する生物種: Proteus mirabilis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21245.76

構造登録者

Wangshu, J.,Knight, S.D. (登録日: 2018-07-12, 公開日: 2018-11-07, 最終更新日: 2024-05-15)

主引用文献

Jiang, W.,Ubhayasekera, W.,Pearson, M.M.,Knight, S.D.
Structures of two fimbrial adhesins, AtfE and UcaD, from the uropathogen Proteus mirabilis.
Acta Crystallogr D Struct Biol, 74:1053-1062, 2018

PubMed Abstract: The important uropathogen Proteus mirabilis encodes a record number of chaperone/usher-pathway adhesive fimbriae. Such fimbriae, which are used for adhesion to cell surfaces/tissues and for biofilm formation, are typically important virulence factors in bacterial pathogenesis. Here, the structures of the receptor-binding domains of the tip-located two-domain adhesins UcaD (1.5 Å resolution) and AtfE (1.58 Å resolution) from two P. mirabilis fimbriae (UCA/NAF and ATF) are presented. The structures of UcaD and AtfE are both similar to the F17G type of tip-located fimbrial receptor-binding domains, and the structures are very similar despite having only limited sequence similarity. These structures represent an important step towards a molecular-level understanding of P. mirabilis fimbrial adhesins and their roles in the complex pathogenesis of urinary-tract infections.

PubMed: 30387764
DOI: 10.1107/S2059798318012391

実験手法

X-RAY DIFFRACTION (1.7 Å)