6H1T

Structure of the BM3 heme domain in complex with clotrimazole

Summary for 6H1T

• Entry DOI: 10.2210/pdb6h1t/pdb
• Descriptor: Bifunctional cytochrome P450/NADPH--P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ... (9 entities in total)
• Functional Keywords: p450, azole inhibitor, heme ligation, p450 bm3, oxidoreductase
• Biological source: Bacillus megaterium
• Total number of polymer chains: 4
• Total formula weight: 216482.16

Authors

Jeffreys, L.N.,Munro, A.W.M.,Leys, D. (deposition date: 2018-07-12, release date: 2019-02-20, Last modification date: 2024-01-17)

• Primary citation: Jeffreys, L.N.,Poddar, H.,Golovanova, M.,Levy, C.W.,Girvan, H.M.,McLean, K.J.,Voice, M.W.,Leys, D.,Munro, A.W.; Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs.; Sci Rep, 9:1577-1577, 2019; PubMed: 30733479; DOI: 10.1038/s41598-018-37330-y

Experimental method

X-RAY DIFFRACTION (2.08 Å)