6H1S
Structure of the BM3 heme domain in complex with fluconazole
Summary for 6H1S
Entry DOI | 10.2210/pdb6h1s/pdb |
Descriptor | Bifunctional cytochrome P450/NADPH--P450 reductase, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total) |
Functional Keywords | p450, azole inhibitor, heme ligation, p450 bm3, oxidoreductase |
Biological source | Bacillus megaterium |
Total number of polymer chains | 2 |
Total formula weight | 107502.22 |
Authors | Jeffreys, L.N.,Munro, A.W.M.,Leys, D. (deposition date: 2018-07-12, release date: 2019-02-20, Last modification date: 2024-01-17) |
Primary citation | Jeffreys, L.N.,Poddar, H.,Golovanova, M.,Levy, C.W.,Girvan, H.M.,McLean, K.J.,Voice, M.W.,Leys, D.,Munro, A.W. Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs. Sci Rep, 9:1577-1577, 2019 Cited by PubMed: 30733479DOI: 10.1038/s41598-018-37330-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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