6H1D

Crystal structure of C21orf127-TRMT112 in complex with SAH

Summary for 6H1D

• Entry DOI: 10.2210/pdb6h1d/pdb
• Descriptor: HemK methyltransferase family member 2, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• Functional Keywords: protein methyltransferase, histone methylation, complex, sah, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 37001.47

Authors

Wang, S.,Hermann, B.,Metzger, E.,Peng, L.,Einsle, O.,Schuele, R. (deposition date: 2018-07-11, release date: 2019-05-22, Last modification date: 2024-01-17)

• Primary citation: Metzger, E.,Wang, S.,Urban, S.,Willmann, D.,Schmidt, A.,Offermann, A.,Allen, A.,Sum, M.,Obier, N.,Cottard, F.,Ulferts, S.,Preca, B.T.,Hermann, B.,Maurer, J.,Greschik, H.,Hornung, V.,Einsle, O.,Perner, S.,Imhof, A.,Jung, M.,Schule, R.; KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.; Nat.Struct.Mol.Biol., 26:361-371, 2019; PubMed: 31061526; DOI: 10.1038/s41594-019-0219-9

Experimental method

X-RAY DIFFRACTION (1.94 Å)