6H1D

Crystal structure of C21orf127-TRMT112 in complex with SAH

6H1D の概要

• エントリーDOI: 10.2210/pdb6h1d/pdb
• 分子名称: HemK methyltransferase family member 2, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• 機能のキーワード: protein methyltransferase, histone methylation, complex, sah, gene regulation
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37001.47

構造登録者

Wang, S.,Hermann, B.,Metzger, E.,Peng, L.,Einsle, O.,Schuele, R. (登録日: 2018-07-11, 公開日: 2019-05-22, 最終更新日: 2024-01-17)

• 主引用文献: Metzger, E.,Wang, S.,Urban, S.,Willmann, D.,Schmidt, A.,Offermann, A.,Allen, A.,Sum, M.,Obier, N.,Cottard, F.,Ulferts, S.,Preca, B.T.,Hermann, B.,Maurer, J.,Greschik, H.,Hornung, V.,Einsle, O.,Perner, S.,Imhof, A.,Jung, M.,Schule, R.; KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.; Nat.Struct.Mol.Biol., 26:361-371, 2019; PubMed: 31061526; DOI: 10.1038/s41594-019-0219-9

実験手法

X-RAY DIFFRACTION (1.94 Å)