6H0U

Glycogen synthase kinase-3 beta (GSK3) complex with a covalent [1,2,4]triazolo[1,5-a][1,3,5]triazine inhibitor

6H0U の概要

• エントリーDOI: 10.2210/pdb6h0u/pdb
• 分子名称: Glycogen synthase kinase-3 beta, (2~{R})-3-[7-azanyl-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl]-2-cyano-propanamide, MALONATE ION, ... (7 entities in total)
• 機能のキーワード: protein kinase, gsk3beta-covalent inhibitor complex, parkinson disease, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94733.37

構造登録者

Marcovich, I.,Demitri, N.,De Zorzi, R.,Storici, P. (登録日: 2018-07-10, 公開日: 2019-05-15, 最終更新日: 2024-01-17)

• 主引用文献: Redenti, S.,Marcovich, I.,De Vita, T.,Perez, C.,De Zorzi, R.,Demitri, N.,Perez, D.I.,Bottegoni, G.,Bisignano, P.,Bissaro, M.,Moro, S.,Martinez, A.,Storici, P.,Spalluto, G.,Cavalli, A.,Federico, S.; A Triazolotriazine-Based Dual GSK-3 beta /CK-1 delta Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition.; Chemmedchem, 14:310-314, 2019; PubMed: 30548443; DOI: 10.1002/cmdc.201800778

実験手法

X-RAY DIFFRACTION (2.3 Å)