6GXU

Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 3

6GXU の概要

• エントリーDOI: 10.2210/pdb6gxu/pdb
• 分子名称: Histone deacetylase, ZINC ION, POTASSIUM ION, ... (7 entities in total)
• 機能のキーワード: epigenetics, histone deacetylase, hdac8, selective inhibitor, pathogen, hydrolase
• 由来する生物種: Schistosoma mansoni (Blood fluke)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 206325.37

構造登録者

Shaik, T.B.,Marek, M.,Romier, C. (登録日: 2018-06-27, 公開日: 2018-08-15, 最終更新日: 2024-01-17)

• 主引用文献: Bayer, T.,Chakrabarti, A.,Lancelot, J.,Shaik, T.B.,Hausmann, K.,Melesina, J.,Schmidtkunz, K.,Marek, M.,Erdmann, F.,Schmidt, M.,Robaa, D.,Romier, C.,Pierce, R.J.,Jung, M.,Sippl, W.; Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis.; ChemMedChem, 13:1517-1529, 2018; PubMed: 29806110; DOI: 10.1002/cmdc.201800238

実験手法

X-RAY DIFFRACTION (1.917 Å)