6GX5

Narrow Pick Filament from Pick's disease brain

Summary for 6GX5

Entry DOI	10.2210/pdb6gx5/pdb
EMDB information	0077
Descriptor	Microtubule-associated protein tau (1 entity in total)
Functional Keywords	tau protein, tau, pick's disease, tauopathy, neurodegenerative disease, proteinopathy, amyloid, filament, helical, pick body, fibril, neurodegeneration, mapt, microtubule-associated protein tau, protein fibril
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	30407.00
Authors	Falcon, B.,Zhang, W.,Murzin, A.G.,Murshudov, G.,Garringer, H.J.,Vidal, R.,Crowther, R.A.,Ghetti, B.,Scheres, S.H.W.,Goedert, M. (deposition date: 2018-06-26, release date: 2018-09-12, Last modification date: 2022-03-30)
Primary citation	Falcon, B.,Zhang, W.,Murzin, A.G.,Murshudov, G.,Garringer, H.J.,Vidal, R.,Crowther, R.A.,Ghetti, B.,Scheres, S.H.W.,Goedert, M. Structures of filaments from Pick's disease reveal a novel tau protein fold. Nature, 561:137-140, 2018 Cited by PubMed: 30158706 DOI: 10.1038/s41586-018-0454-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation