6GX5

Narrow Pick Filament from Pick's disease brain

6GX5 の概要

• エントリーDOI: 10.2210/pdb6gx5/pdb
• EMDBエントリー: 0077
• 分子名称: Microtubule-associated protein tau (1 entity in total)
• 機能のキーワード: tau protein, tau, pick's disease, tauopathy, neurodegenerative disease, proteinopathy, amyloid, filament, helical, pick body, fibril, neurodegeneration, mapt, microtubule-associated protein tau, protein fibril
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 30407.00

構造登録者

Falcon, B.,Zhang, W.,Murzin, A.G.,Murshudov, G.,Garringer, H.J.,Vidal, R.,Crowther, R.A.,Ghetti, B.,Scheres, S.H.W.,Goedert, M. (登録日: 2018-06-26, 公開日: 2018-09-12, 最終更新日: 2024-07-10)

• 主引用文献: Falcon, B.,Zhang, W.,Murzin, A.G.,Murshudov, G.,Garringer, H.J.,Vidal, R.,Crowther, R.A.,Ghetti, B.,Scheres, S.H.W.,Goedert, M.; Structures of filaments from Pick's disease reveal a novel tau protein fold.; Nature, 561:137-140, 2018; PubMed: 30158706; DOI: 10.1038/s41586-018-0454-y

実験手法

ELECTRON MICROSCOPY (3.2 Å)