6GWU

Carbonic anhydrase CaNce103p from Candida albicans

6GWU の概要

• エントリーDOI: 10.2210/pdb6gwu/pdb
• 分子名称: Carbonic anhydrase, ZINC ION, BETA-MERCAPTOETHANOL, ... (6 entities in total)
• 機能のキーワード: carbonic anhydrase, candida albicans, cance103p, substrate tunnel, lyase
• 由来する生物種: Candida albicans (Yeast)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 93197.89

構造登録者

Brynda, J.,Dostal, J.,Heidingsfeld, O.,Machacek, S.,Blaha, J.,Pichova, I. (登録日: 2018-06-26, 公開日: 2018-11-07, 最終更新日: 2024-01-17)

主引用文献

Dostal, J.,Brynda, J.,Blaha, J.,Machacek, S.,Heidingsfeld, O.,Pichova, I.
Crystal structure of carbonic anhydrase CaNce103p from the pathogenic yeast Candida albicans.
BMC Struct. Biol., 18:14-14, 2018

PubMed Abstract: The pathogenic yeast Candida albicans can proliferate in environments with different carbon dioxide concentrations thanks to the carbonic anhydrase CaNce103p, which accelerates spontaneous conversion of carbon dioxide to bicarbonate and vice versa. Without functional CaNce103p, C. albicans cannot survive in atmospheric air. CaNce103p falls into the β-carbonic anhydrase class, along with its ortholog ScNce103p from Saccharomyces cerevisiae. The crystal structure of CaNce103p is of interest because this enzyme is a potential target for surface disinfectants.

PubMed: 30367660
DOI: 10.1186/s12900-018-0093-4

実験手法

X-RAY DIFFRACTION (2.2 Å)