6GVH

Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-4-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine

6GVH の概要

• エントリーDOI: 10.2210/pdb6gvh/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine (3 entities in total)
• 機能のキーワード: lipid kinase, inhibitor, pi3k alpha, transferase-transferase inhibitor complex, transferase-transferase regulator complex, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 112397.27

構造登録者

Ouvry, G.,Aurelly, M.,Bonnary, L.,Borde, E.,Bouix-Peter, C.,Chantalat, L.,Clary, L.,Defoin-Platel, C.,Deret, S.,Forissier, M.,Harris, C.S.,Isabet, T.,Lamy, L.,Luzy, A.P.,Pascau, J.,Soulet, C.,Taddei, A.,Taquet, N.,Tomas, L.,Thoreau, E.,Varvier, E.,Vial, E.,Hennequin, L.F. (登録日: 2018-06-21, 公開日: 2019-10-02, 最終更新日: 2024-05-15)

• 主引用文献: Ouvry, G.,Clary, L.,Tomas, L.,Aurelly, M.,Bonnary, L.,Borde, E.,Bouix-Peter, C.,Chantalat, L.,Defoin-Platel, C.,Deret, S.,Forissier, M.,Harris, C.S.,Isabet, T.,Lamy, L.,Luzy, A.P.,Pascau, J.,Soulet, C.,Taddei, A.,Taquet, N.,Thoreau, E.,Varvier, E.,Vial, E.,Hennequin, L.F.; Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors.; Acs Med.Chem.Lett., 10:1561-1567, 2019; PubMed: 31749911; DOI: 10.1021/acsmedchemlett.9b00401

実験手法

X-RAY DIFFRACTION (2.74 Å)