6GVH
Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-4-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine
6GVH の概要
エントリーDOI | 10.2210/pdb6gvh/pdb |
分子名称 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine (3 entities in total) |
機能のキーワード | lipid kinase, inhibitor, pi3k alpha, transferase-transferase inhibitor complex, transferase-transferase regulator complex, transferase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 112397.27 |
構造登録者 | Ouvry, G.,Aurelly, M.,Bonnary, L.,Borde, E.,Bouix-Peter, C.,Chantalat, L.,Clary, L.,Defoin-Platel, C.,Deret, S.,Forissier, M.,Harris, C.S.,Isabet, T.,Lamy, L.,Luzy, A.P.,Pascau, J.,Soulet, C.,Taddei, A.,Taquet, N.,Tomas, L.,Thoreau, E.,Varvier, E.,Vial, E.,Hennequin, L.F. (登録日: 2018-06-21, 公開日: 2019-10-02, 最終更新日: 2024-05-15) |
主引用文献 | Ouvry, G.,Clary, L.,Tomas, L.,Aurelly, M.,Bonnary, L.,Borde, E.,Bouix-Peter, C.,Chantalat, L.,Defoin-Platel, C.,Deret, S.,Forissier, M.,Harris, C.S.,Isabet, T.,Lamy, L.,Luzy, A.P.,Pascau, J.,Soulet, C.,Taddei, A.,Taquet, N.,Thoreau, E.,Varvier, E.,Vial, E.,Hennequin, L.F. Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Acs Med.Chem.Lett., 10:1561-1567, 2019 Cited by PubMed: 31749911DOI: 10.1021/acsmedchemlett.9b00401 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.74 Å) |
構造検証レポート
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