6GUK

CDK2 in complex with CGP74514A

Summary for 6GUK

Entry DOI	10.2210/pdb6guk/pdb
Descriptor	Cyclin-dependent kinase 2, ~{N}2-[(1~{R},2~{S})-2-azanylcyclohexyl]-~{N}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine (3 entities in total)
Functional Keywords	cdk2, inhibitor, cell cycle
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35147.24
Authors	Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. (deposition date: 2018-06-19, release date: 2018-12-05, Last modification date: 2024-01-17)
Primary citation	Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol, 26:121-130.e5, 2019 Cited by PubMed: 30472117 DOI: 10.1016/j.chembiol.2018.10.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation